Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial.

ABSTRACT:

Rationale & objective

Uromodulin (UMOD) is the most abundant protein found in urine and has emerged as a promising biomarker of tubule health. Circulating UMOD is also detectable, but at lower levels. We evaluated whether serum UMOD levels were associated with the risks of incident kidney failure with replacement therapy (KFRT) and mortality.

Study design

Prospective cohort.

Setting & participants

Participants in AASK (the African American Study of Kidney Disease and Hypertension) with available stored serum samples from the 0-, 12-, and 24-month visits for biomarker measurement.

Predictors

Baseline log-transformed UMOD and change in UMOD over 2 years.

Outcomes

KFRT and mortality.

Analytical approach

Cox proportional hazards and mixed-effects mode

SUBMITTER: Chen TK 

PROVIDER: S-EPMC12694560 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature