Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction: Insights into Early-Phase HIV Vascular Dysfunction.

ABSTRACT:

Background

People with HIV (PWH), even with sustained viral suppression on antiretroviral therapy (ART), remain at increased risk for cardiovascular disease. Coronary endothelial dysfunction, a sensitive marker of early vascular injury and a potential target for intervention is common in this population, but its biological basis remains unknown.

Methods

We performed a cross-sectional study combining in vivo coronary MRI and high-throughput serum proteomics to investigate mechanisms of coronary endothelial dysfunction in treated HIV. Forty-five virally suppressed PWH and twenty-nine age- and sex-matched healthy controls underwent coronary MRI during isometric handgrip exercise to quantify coronary endothelial function, defined as the percentage change in coronary cross

SUBMITTER: Keole KS 

PROVIDER: S-EPMC12694598 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature