Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally.

ABSTRACT: Early life stress (ELS) increases the likelihood of developing chronic health problems including mental illness. In humans, deficits in social behavior often emerge during adolescence and correlate with later-life psychiatric diagnoses. We examined in mice the effects of a limited bedding and nesting (LBN) model of ELS on pup ultrasonic vocalizations (USVs) during postnatal days 3-9 (P3-P9). Then on P30, an adolescent timepoint, we assessed social behavior as well as thymus involution and adrenal hypertrophy, both biomarkers of stress. We found reductions in USVs as early as P3, resembling low levels normally seen later in development. There were few changes in SI, with deficits observed only after restraint stress in female LBN mice. Surprisingly, thymus weights were augmented and adrenal

SUBMITTER: McGowan JC 

PROVIDER: S-EPMC12694602 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature