Modeling the Synergetic Dynamics of B cells and T_FH cells in Germinal Center Reactions.

ABSTRACT: B cells producing high-affinity antibodies arise through affinity maturation within germinal centers (GCs), where selection is driven by T follicular helper (T_FH) cells. Recent studies have shown that, like GC B cells, T_FH cells also undergo antigen-dependent selection, with competition among T_FH clones dictated by their ability to recognize and stimulate B cells. This sensitivity-dependent selection process leads to dynamic remodeling of the T_FH repertoire over time. Despite the essential role of T_FH cells in B cell selection, the functional consequences of the time evolution of the T_FH cell population remains poorly understood. To address this gap, we developed a population dynamics model that explicitly incorporates key T

SUBMITTER: Pyo AGT 

PROVIDER: S-EPMC12694604 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature