Differential plasticity of excitatory and inhibitory reticulospinal fibers after spinal cord injury: Implication for recovery.

ABSTRACT: JOURNAL/nrgr/04.03/01300535-202605000-00035/figure1/v/2025-10-21T121913Z/r/image-tiff The remodeling of axonal connections following injury is an important feature driving functional recovery. The reticulospinal tract is an interesting descending motor tract that contains both excitatory and inhibitory fibers. While the reticulospinal tract has been shown to be particularly prone to axonal growth and plasticity following injuries of the spinal cord, the differential capacities of excitatory and inhibitory fibers for plasticity remain unclear. As adaptive axonal plasticity involves a sophisticated interplay between excitatory and inhibitory input, we investigated in this study the plastic potential of glutamatergic (vGlut2) and GABAergic (vGat) fibers originating from the gigantocellular nu

SUBMITTER: Jeleva R 

PROVIDER: S-EPMC12694638 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature