Drug-delivery strategies using biomaterials in the field of nerve regeneration.

ABSTRACT: Neural injuries can cause considerable functional impairments, and both central and peripheral nervous systems have limited regenerative capacity. The existing conventional pharmacological treatments in clinical practice show poor targeting, rapid drug clearance from the circulatory system, and low therapeutic efficiency. Therefore, in this review, we have first described the mechanisms underlying nerve regeneration, characterized the biomaterials used for drug delivery to facilitate nerve regeneration, and highlighted the functionalization strategies used for such drug-delivery systems. These systems mainly use natural and synthetic polymers, inorganic materials, and hybrid systems with advanced drug-delivery abilities, including nanoparticles, hydrogels, and scaffold-based systems. Then,

SUBMITTER: Xu L 

PROVIDER: S-EPMC12694642 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature