Prefrontal Cortex Recruitment to Food Stimuli Differs in Overweight/Obesity and Binge Eating Disorder.

ABSTRACT:

Background

At a phenotypical level, the repeated occurrence of binge eating episodes clearly differentiates individuals with binge eating disorder (BED) from individuals with overweight but without BED. Their neural profiles during food-related inhibition, however, indicate prefrontal hypoactivation in both groups. The present study investigated differential neural activations in upper lateral (right dorsolateral prefrontal cortex [DLPFC]) and inferior (right inferior frontal gyrus [IFG]) control regions during food-related inhibition by functional near-infrared spectroscopy (fNIRS). In addition, activity in reward-related brain regions (orbitofrontal cortex [OFC]) during stimulus processing was measured.

Method

Individuals with BED (n = 32), a control group of individuals w

SUBMITTER: Svaldi J 

PROVIDER: S-EPMC12694698 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature