NtRoot: computational inference of human ancestry at scale from genomic data.

ABSTRACT:

Motivation

Ancestry information is essential to large cohort studies but is often unavailable or inconsistently measured. For studies involving genome sequencing, existing ancestry prediction methods are constrained by computational demands and complex input requirements. Efficient, scalable approaches are needed to infer ancestry directly from sequencing data while maintaining accuracy and reproducibility.

Results

We present ntRoot, a computationally lightweight method for inferring human super-population-level ancestry from whole genome assemblies or short or long sequencing data. Utilizing a reference-guided, alignment-free single nucleotide variant detection framework, ntRoot employs a succinct Bloom filter to efficiently query diverse genomic inputs against a variant re

SUBMITTER: Warren RL 

PROVIDER: S-EPMC12695050 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature