Tacrolimus as first-line therapy in a US cohort of idiopathic inflammatory myopathies related interstitial lung disease.

ABSTRACT:

Objectives

Calcineurin inhibitors are commonly used to treat idiopathic inflammatory myopathies related interstitial lung disease (IIM-ILD) in Asia but not in the USA. Here, we evaluate the efficacy of tacrolimus (TAC) as first-line immunosuppressive therapy in a US cohort of IIM-ILD.

Methods

This retrospective, single-centre cohort study evaluated the change in absolute forced vital capacity (FVCabs) in IIM-ILD participants after 12 months of treatment with mycophenolate mofetil (MMF), azathioprine (AZA) or TAC. Participants were naïve to immunosuppressive agents other than glucocorticoids and/or intravenous immunoglobulin. Treatment with MMF, AZA or TAC was at the discretion of their primary clinician. Additional outcomes were transplant-free survival, prednisone use and s

SUBMITTER: Harris KJR 

PROVIDER: S-EPMC12695053 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature