Mediating effect of cognitive reserve on associations between processing speed and memory in older adults with and without multiple sclerosis.

ABSTRACT:

Objective

Slower processing speed is implicated in memory impairment in both aging and multiple sclerosis (MS). Cognitive reserve serves as a buffer against memory decline and dementia, but no studies have reported on its mediating effect on the associations between processing speed and memory. Therefore, we investigated whether cognitive reserve mediated the relationship between processing speed and verbal memory in older adults and whether the presence of MS modified this association.

Method

Older adults with MS (n = 104; M_age = 64.84 ± 4.36 years) and healthy controls (HCs: n = 105; M_age = 68.33 ± 7.24 years) underwent neuropsychological testing and brain magnetic resonance imaging. Cognitive reserve was derived using resi

SUBMITTER: Fox A 

PROVIDER: S-EPMC12695057 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature