Effect of frequency on dual target deep brain stimulation.

ABSTRACT:

Background

Deep brain stimulation reduces the motor symptoms of Parkinson's disease (PD). Dual target deep brain stimulation (DT DBS) may better reduce symptoms and minimize side effects than single target, but the optimal parameters of DT DBS are unknown.

Objective

To quantify the frequency response of DT DBS on bradykinesia and beta oscillations, and to explore intrahemispheric pulse delay shifts as a means to reduce total energy delivered.

Methods

We applied DT DBS using the Summit RC + S in six participants with PD, varying DBS frequency. We further examined the effects of frequency in a biophysical model.

Results

DT DBS at 50 Hz was effective at reducing bradykinesia, whereas increasing DT DBS frequency up to 125 Hz also led to significantly lower beta pow

SUBMITTER: Rodriguez Capilla R 

PROVIDER: S-EPMC12695076 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature