Targeted Phototriggered and pH-Responsive Micellar Cancer Drug Delivery System with Real-Time Monitoring through the NSET Mechanism.

ABSTRACT: A phototriggered and pH-responsive cancer drug delivery system based on polymeric micelles was formulated, utilizing easily available and cost-effective materials such as an amphiphilic diblock copolymer (mPEG-PLA) and a Spiropyran derivative. It addressed the major challenges in drug delivery systems, i.e., monitoring real-time drug release, targeted, and on-demand drug delivery. To monitor real-time drug release, the fluorescence quenching of the cancer drug, doxorubicin (DOX), by in situ synthesized gold nanoparticles (AuNPs) through the Nanomaterial Surface Energy Transfer (NSET) mechanism was explored. Photoisomerization and size switching were characterized using UV-vis spectroscopy and dynamic light scattering (DLS) techniques. The NSET process during in situ synthesis

SUBMITTER: Dyagala S 

PROVIDER: S-EPMC12695090 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature