Association Between Arterial Stiffness and Bone Microarchitectural Deterioration in Type 2 Diabetes: A Cross-Sectional Study.

ABSTRACT:

Background

Trabecular bone score (TBS) and brachial-ankle pulse wave velocity (baPWV) are established indicators of bone microstructure and arterial stiffness. However, their association has not been explored in the context of type 2 diabetes (T2DM). We aimed to investigate the factors influencing bone microarchitectural deterioration in patients with T2DM, examining the associations of baPWV with both TBS and bone mineral density (BMD).

Materials and methods

This study comprised 646 participants with T2DM. L1-L4 TBS was assessed via dual-energy X-ray bone densitometry and categorized into three groups. Independent risk factors influencing L1-L4 TBS in T2DM patients were examined by stepwise linear regression. The independent association between baPWV and TBS was further ana

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12695132 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature