Risk Factor-Targeted Perioperative Care Reduces Anastomotic Leakage After Colorectal Surgery: The DoubleCheck Study.

ABSTRACT:

Objective

The DoubleCheck study aimed to introduce preoperative and perioperative interventions minimizing exposure to modifiable risk factors and determine their effect on colorectal anastomotic leakage (CAL).

Background

CAL is a severe complication. To predict and prevent its occurrence, the LekCheck study identified intraoperative modifiable risk factors for CAL: anemia, hyperglycemia, hypothermia, incorrect timing of antibiotic prophylaxis, administration of vasopressors, and epidural analgesia.

Methods

This international open-labeled interventional study was performed between September 2021 and December 2023. An enhanced care bundle consisting of anemia correction, glucose measurement, attaining normothermia, antibiotics administration within 60 to 15 minutes pre

SUBMITTER: de Wit A 

PROVIDER: S-EPMC12695192 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature