Relative Risk of Retinal Detachment in COL2A1 Compared with COL11A1 Stickler Syndrome: An Individual Patient Data Meta-Analysis.

ABSTRACT:

Topic

To compare the relative risk of retinal detachment between patients with COL2A1 and COL11A1 Stickler syndrome.

Clinical relevance

It is unclear whether the rate of retinal detachment differs between COL2A1 and COL11A1 Stickler syndrome. Previous studies included too few patients to detect a difference between genotypes.

Methods

Individual patient data meta-analysis of cohort studies, case-control studies, cross-sectional studies, case series, and case reports across the MEDLINE, Embase, Scopus, Web of Science Core Collection, and Web of Science Preprint Citation Index databases from 1991 to 2025. Articles providing eye examination results in subjects with genetically confirmed COL2A1 or COL11A1 Stickler syndrome were included. From the included articles, individ

SUBMITTER: Carpenter CM 

PROVIDER: S-EPMC12695437 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature