Validation of Dynamic Deuterium Metabolic Imaging (DMI) for the Measurement of Cerebral Metabolic Rates of Glucose in Rat.

ABSTRACT: Deuterium metabolic imaging (DMI) is an innovative technique in which ²H magnetic resonance spectroscopic imaging (MRSI) is utilized to determine the metabolic activity of administered ²H-labeled substrates. As such it can be viewed as the ²H counterpart to more traditional ¹³C labeling methods that can be considered the gold standard for metabolic mapping in vivo. To ensure reliable findings from dynamic ²H MRSI experiments about absolute metabolic flux rates after administration of a ²H-labeled substrate it is essential to take into account ²H-specific aspects, namely ²H label losses and kinetic isotopy effects (KIEs). Here, a modified version of a ¹³C-based metabolic model for glucose meta

SUBMITTER: Mathy CS 

PROVIDER: S-EPMC12695439 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature