Proteome-Guided Drug Target Discovery for Periodontitis.

ABSTRACT:

Background and objective

Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease.

Materials and methods

We integrated proteomics data from deCODE genetics with periodontitis genome-wide association studies (GWAS) from the Million Veteran Program to identify proteins associated with periodontitis. Findings were replicated using GWAS data from the Gene-Lifestyle Interactions in Dental Endpoints consortium. Causal associations were validated using genetic and statistical methods, and the identified proteins were assessed for biological relevance and druggability.

Results

Among the 2088 evaluated proteins, three showed robust evidence of

SUBMITTER: Alayash Z 

PROVIDER: S-EPMC12695451 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature