Delta power surge and alpha power decline in traumatic brain injury recovery: A quantitative EEG analysis of the CAPTAIN-rTMS trial.

ABSTRACT:

Introduction

Traumatic brain injury (TBI) is a leading cause of disability and death. Both repetitive transcranial magnetic stimulation (rTMS) and Cerebrolysin (CRB) are promising therapies regulating neural plasticity. This study aimed to assess the changes in resting-state brain activity following CRB, rTMS, or combined CRB-rTMS therapy.

Methods

This secondary analysis of the CAPTAIN-rTMS trial analyzed eyes-closed segments from EEG recordings at 30 days (baseline) and 180 days (after treatment) respectively. We computed relative power spectral densities for delta, theta, alpha and beta frequency bands, for the entire scalp and different regions. We conducted neuropsychological assessments and evaluated the correlations between resting-state relative power spectral density

SUBMITTER: Livint-Popa L 

PROVIDER: S-EPMC12695505 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature