Antibiotic-induced gut microbiota depletion enhances glucose tolerance linked to GLP-1 signaling.

ABSTRACT:

Introduction

Depletion of the gut microbiota is known to improve glucose metabolism and modify thermogenic capacity in mice. However, the underlying mechanisms remain unclear. In this study, we aimed to determine whether the browning effect observed after antibiotic treatment contributes to metabolic modifications and to investigate the potential central role of GLP-1 in enhancing glucose metabolism.

Methods

Using an inducible Ucp1DTR mouse model to transiently ablate UCP1⁺ cells, we assessed glucose tolerance, cold sensitivity, and circulating GLP-1 levels following gut microbiota depletion. We additionally examined GLP-1 levels in germ-free mice. Glucose tolerance was compared to GLP1R KO mice following gut microbiota depletion. Bile acid profiling in wild-type

SUBMITTER: Kellenberger A 

PROVIDER: S-EPMC12695531 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature