Analysis of blood untargeted metabolomic characteristics of different subtypes of rosacea.

ABSTRACT:

Background

Rosacea is a chronic inflammatory skin disease characterized by vascular and neurological dysregulation, presenting with diverse clinical subtypes whose pathological mechanisms remain incompletely elucidated. Recent studies suggest that metabolic dysregulation may play a key role in disease onset and progression; however, systematic metabolomic studies targeting different subtypes remain limited.

Objective

This study employed untargeted metabolomic analysis to systematically compare plasma metabolic characteristic differences between patients with erythematotelangiectatic rosacea (ETR), papulopustular rosacea (PPR), and healthy controls (HC), aiming to identify potential disease biomarkers and provide new insights for understanding the pathogenesis of rosacea.

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12695568 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature