G-protein coupled receptors synergy in bone health: new avenues for osteoporosis detection and <i>in vitro</i> modeling.

ABSTRACT: Osteoporosis remains a substantial healthcare burden in modern times. Current diagnostic methods of osteoporosis detect changes in bone mineral density and microarchitecture, which have already occurred. It is critically important to develop methods of early diagnosis of osteoporosis to be able to plan early interventions in order to stop the disease progression. Genetic screening based on early osteoporosis marker genes appears to be a promising approach for early diagnosis and prevention. However, a significant gap exists in this area of knowledge. Recently, we identified a novel combination of three single nucleotide polymorphisms - FSHR (rs6166) AA, TSHR (rs1991517) CC, and ADRB2 (rs1042713) AA, with a high prevalence among osteoporotic patients. Subsequent functio

SUBMITTER: Sopova JV 

PROVIDER: S-EPMC12695586 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature