Gentamicin-loaded exosomes from IMMUNEPOTENT CRP enhance healing of infected diabetic wound in mice.

ABSTRACT:

Introduction

Diabetic foot infections (DFIs) are a major cause of lower extremity amputations and are associated with substantial morbidity and reduced quality of life. Given the limited efficacy of current treatments and the rise of antimicrobial resistance, there is an urgent need for innovative therapeutic approaches. This study evaluates the use of exosomes derived from a bovine leukocyte spleen extract (IMMUNEPOTENT CRP), loaded with gentamicin, to improve infection control and promote wound healing in a diabetic setting.

Methods

The efficiency of gentamicin encapsulation were evaluated followed by gentamicin release under acidic and alkaline conditions. A wound model was established in streptozotocin (STZ)-induced diabetic mice, followed by inoculation with Staphylo

SUBMITTER: Garcia Coronado PL 

PROVIDER: S-EPMC12695595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature