Environmental exposure to per- and polyfluoroalkyl substances and childhood congenital heart disease: a mixed analysis.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) exposure is associated with various health risks. However, limited research has explored their potential connection with congenital heart disease (CHD).

Objective

This study aimed to investigate the relationship between different types of PFAS and childhood CHD using a mixed analysis approach.

Methods

A hospital-based case-control study was conducted involving 282 children with CHD and 282 control participants. Plasma samples were analyzed for 19 PFAS congeners. Logistic regression, Bayesian kernel-machine regression (BKMR), and weighted quantile sum (WQS) models were employed to assess the association between individual PFAS and PFAS mixtures with CHD risk.

Results

Analysis of 564 subjects revealed higher p

SUBMITTER: Jiao X 

PROVIDER: S-EPMC12695596 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature