Intermittent immunoadsorption in critically ill patients with neuroimmunological disorders: a retrospective study.

ABSTRACT:

Objectives

This study aimed to evaluate the efficacy and safety of intermittent immunoadsorption (IA) in critically ill patients with refractory autoimmune neurological disorders.

Methods

We retrospectively reviewed 13 patients admitted to the neurocritical care unit with severe autoimmune encephalitis, Guillain-Barré syndrome, neuromyelitis optica spectrum disorders, or chronic inflammatory demyelinating polyneuropathy, all of whom had failed first-line immunotherapy (intravenous methylprednisolone and/or intravenous immunoglobulin). IA was administered intermittently, with schedules individualized based on clinical status.

Results

The modified Rankin Scale (mRS) improved significantly following IA (p = 0.02), while the Acute Physiology and Chronic Health Eval

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12695613 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature