A T2-weighted MRI grading system for preoperative prediction of visceral pleural invasion in small non-small cell lung cancers.

ABSTRACT:

Purpose

To evaluate the supplemental diagnostic value of T2WI for assessing VPI in NSCLC ≤3 cm with indeterminate CT features (pleural contact/tags).

Materials and methods

This prospective single-center study enrolled 138 participants with NSCLC ≤3 cm and CT-suspected pleural involvement, of whom 98 underwent surgical resection and histopathologic VPI confirmation from January 2021 to March 2023. All participants underwent thoracic MRI (3.0T), including T2WI sequences. Two radiologists independently graded tumor-pleural interface signals (Grades 0-3: absent to wedge-shaped hyperintensity). Pathologic VPI served as the reference standard. Logistic regression and ROC analysis were performed to develop a predictive model integrating tumor size and T2WI grades.

Results

VP

SUBMITTER: Zhang N 

PROVIDER: S-EPMC12695614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature