Direct deaminative functionalization with N-nitroamines.

ABSTRACT: Amines are among the most common functional groups in bioactive molecules¹. Despite this prevalence, conventional means of converting aromatic amines rely heavily on diazonium intermediates², which pose significant safety risks due to the explosive nature of these salts^3,4. Here we report a direct deaminative strategy through the formation of N-nitroamines, allowing the direct conversion of inert aromatic C-N bonds into an array of other functional groups, including C-X (C-Br, C-Cl, C-I, C-F, C-N, C-S, C-Se, C-O) and C-C bonds. This operationally simple, general protocol establishes a unified strategy for one-pot deaminative cross-couplings by integrating deaminative functionalization with transition-metal-catalysed arylation, thereby streamlining synthesis

SUBMITTER: Tu G 

PROVIDER: S-EPMC12695646 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature