From standard to stratified: Modeling NTCP and EAR to personalize daily MV-CBCT in radiotherapy.

ABSTRACT:

Purpose

To evaluate the cumulative radiobiological impact of daily megavoltage cone-beam computed tomography (MV-CBCT) imaging dose based on normal tissue complication probability (NTCP) and excess absolute risk (EAR) of secondary malignancies among radiotherapy patients treated for breast, pelvic, and head & neck cancers. This study investigated whether MV-CBCT imaging dose warrants protocol personalization according to patient age, anatomical treatment site, and organ-specific radiosensitivity.

Methods

This retrospective study included cohorts of breast (n = 30), pelvic (n = 17), and head & neck (n = 20) cancer patients undergoing radiotherapy with daily MV-CBCT. Imaging dose distributions employing two common MV-CBCT protocols (5 and 10 MU per fraction) were analyzed. NTC

SUBMITTER: Tai DT 

PROVIDER: S-EPMC12695683 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature