NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma.

ABSTRACT:

Background

The inflammasome NLRP3 (NOD-like receptor family pyrin domain containing 3) is critical for epithelial barrier integrity. Allergic asthma is characterized by airway inflammation, airway hyperresponsiveness (AHR), and mucus hypersecretion. To date, the key players and underlying mechanisms in the interaction between NLRP3 and epithelial barrier integrity in type 2-mediated allergic asthma are poorly understood.

Objective

Our study aims to evaluate the protective mechanisms of NLRP3 on airway epithelium and its structural and functional components during type 2-mediated allergic asthma inflammation.

Methods

Using an experimental model of allergic airway disease, NLRP3-deficient (NLRP3^-/-) and wild-type (WT) mice were analyzed for AHR, mucus hyperpl

SUBMITTER: DeStefano S 

PROVIDER: S-EPMC12695735 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature