Association of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.

ABSTRACT:

Background

Timely administration of antenatal corticosteroids improves preterm outcomes; however, in low- and middle-income countries (LMICs), multiple barriers often delay treatment. Whether exposure within 24 h before delivery confers benefits remains uncertain. We aimed to evaluate the association between antenatal dexamethasone-to-delivery intervals and preterm outcomes in an LMIC setting.

Methods

This single-center prospective cohort study was conducted at a tertiary neonatal intensive care unit in India from June 2023 to December 2024. The participants were preterm infants born at 24 0/7-33 6/7 week gestation. Exclusion criteria were major congenital anomalies, multiple courses of dexamethasone, administration-to-birth interval > 7 d, and interfacility transfer. The ex

SUBMITTER: Kalrao V 

PROVIDER: S-EPMC12695745 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature