IFN-γ induced the formation of foamy macrophages via CD40 signal to control <i>Mycobacterium abscessus</i> pulmonary infection.

ABSTRACT:

Background

Foamy macrophages (FMs) have recently shown potential in restricting the intracellular growth of Mycobacterium. However, the mechanism behind the formation of FMs and their significance in the pathophysiology of Mycobacterium abscessus (M. abscessus)-induced pulmonary infections remains poorly understood.

Methods

Clinical blood samples, murine infected models (WT and IFN-γ^-/- mice), and macrophage infected models were utilized to investigate the formation of FMs mediated by IFN-γ and its critical role in bacterial control during M. abscessus infection. Oil Red O staining and confocal microscopy were employed to assess the effect of IFN-γ on FMs formation in vivo and in vitro, coupled with specific signaling path

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12695758 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature