Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration.

ABSTRACT:

Background

Klotho is a longevity-associated protein found in membrane-bound and secreted forms, with the latter detectable in blood and cerebrospinal fluid (CSF). Circulating Klotho mainly originates from the kidney, while the choroid plexus (CP) secretes it into the CSF. CP dysfunction is associated with reduced Klotho expression and neurodegeneration and may result in CP enlargement on magnetic resonance imaging (MRI). In this preliminary study, we investigated Klotho levels in neurodegenerative patients and their association with CP enlargement.

Materials and methods

We retrospectively analyzed 40 patients from the IRCCS Ca' Granda Ospedale Policlinico, Milan, including 32 neurodegenerative patients (Deg) and 8 cognitively normal controls (NonDeg). CSF and serum Klotho le

SUBMITTER: Sacchi L 

PROVIDER: S-EPMC12695769 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature