Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells.

ABSTRACT:

Ethnopharmacological relevance

Shaoyao Gancao Decoction (SGD) is a renowned traditional Chinese medicinal formulation widely utilized in Asia. It is particularly effective in treating spastic, painful, and inflammatory conditions, especially gynecological pain disorders. However, the underlying mechanisms of its action remain largely unexplored.

Aims of the study

To investigate the potential molecular mechanism by which SGD inhibits autophagy and apoptosis in ectopic endometrial stromal cells (EESCs), thereby elucidating the pathway responsible for its anti-adenomyosis effects.

Materials and methods

Four types of tissues were collected for detection, including AM ectopic endometrium, AM eutopic endometrium, normal myometrium, and normal endometrium. Meanwhile, EESCs w

SUBMITTER: Lai H 

PROVIDER: S-EPMC12695794 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature