Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) constitute the most abundant immune cell population in the glioblastoma (GBM) tumor microenvironment. These macrophages critically influence multiple pathological processes in GBM, including recurrence, drug resistance, and immune evasion. However, the role of TREM1 in mediating proneural-to-mesenchymal transition (PMT) in TAMs remains unclear.

Methods

Single-cell RNA sequencing analysis of 24,366 cells from seven GBM patients identified nine distinct cellular populations, including TAMs and malignant cells. Deconvolution analysis of TCGA mRNA-seq data complemented these findings. Differential expression analysis, weighted gene co-expression network analysis, and LASSO-Cox regression consistently identified TREM1 in TAMs as a PM

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12695795 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature