Effectiveness of treatments to prevent femoral periprosthetic bone loss following total hip arthroplasty: a network meta-analysis.

ABSTRACT:

Background

The objective of this study was to conduct a systematic review and network meta-analysis (NMA) to compare the efficacy of various anti-osteoporosis drugs in preventing femoral periprosthetic bone loss following total hip arthroplasty (THA).

Methodology

Randomized controlled trials (RCTs) assessing the clinical efficacy of various anti-osteoporosis drugs and control treatments in preventing periprosthetic bone loss following THA were identified. Outcomes evaluated included bone mineral density (BMD) at 6 months, 12 months, 24 months, and 5-10 years. The network meta-analysis was conducted using Stata 13.0 and R-3.5.1 software with the "gemtc" package.

Results

A total of 33 RCTs with 1,169 patients were included. At 6 months, alendronate, alendronate + alfaca

SUBMITTER: Zhao ZH 

PROVIDER: S-EPMC12695822 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature