Safety and efficacy comparison of single-stage and two-stage ERCP combined with laparoscopic cholecystectomy: a meta-analysis and systematic review.

ABSTRACT:

Objective

This meta-analysis aims to assess the safety and efficacy of single-stage and two-stage ERCP combined with laparoscopic cholecystectomy in the management of bile duct stones.

Methods

A comprehensive search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases to identify prospective randomized controlled studies comparing the effectiveness of single-stage ERCP combined with laparoscopy, also known as Laparoscopic-Endoscopic Rendezvous (LERV), and the sequential two-step approach of ERCP followed by laparoscopic cholecystectomy (ERCP+LC). Stone clearance success rate, incidence of complications, occurrence of pancreatitis, and hyperamylasemia were analyzed using Stata software.

Results

Nine studies involving a total of 1,003 particip

SUBMITTER: Tai JX 

PROVIDER: S-EPMC12695829 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature