Higher frequency of prokaryotic low complexity regions in core and orthologous genes.

ABSTRACT: Prokaryotic genome evolution is shaped by mutation, gene duplication, and horizontal gene transfer, yet the interaction of these mechanisms, particularly in relation to low complexity regions (LCRs), remains poorly understood. LCRs are known to be mutation-prone and have been proposed to promote genetic innovation. However, the interaction between LCR-mediated and paralogy-mediated genetic innovation is still unclear. To clarify the interplay between these two evolutionary forces, we analyzed the distribution of LCRs in protein-coding genes from three closely related enterobacteria (Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae) at both species and population levels. Using pangenomic and orthology-based approaches, we categorized genes by duplication

SUBMITTER: Saravanan V 

PROVIDER: S-EPMC12695832 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature