Leukocyte mRNA sequencing reveals unfolded protein response activation in severe heat stroke in Japan.

ABSTRACT:

Background

Severe heat stroke can cause multi-organ dysfunction and can be fatal, yet its underlying pathophysiology remains poorly understood. While RNA alterations are known to occur in critical illness, their specific role in severe heat stroke has not been comprehensively studied. Understanding these molecular changes may improve diagnostic and therapeutic strategies. This study aimed to investigate the pathogenesis of severe heat stroke by analyzing RNA expression profiles in Japanese patients in comparison to healthy controls.

Results

This single-center, prospective, observational study included seven patients (median age: 69 ± 21.5 years; 57.1% male) with severe heat stroke admitted to Osaka University Hospital Emergency Center between August 2020 and July 2021, along

SUBMITTER: Nomura Y 

PROVIDER: S-EPMC12695859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature