Sustainable purification-free synthesis of N-H ketimines by solid acid catalysis.

ABSTRACT: Among imines, nitrogen-unprotected ketimines (N-H ketimines) are valuable precursors to nitrogen-containing compounds. However, their applications are limited compared with those of nitrogen-protected ketimines (N-R ketimines) owing to difficulties in synthesis and purification. We develop remarkably simple methods for synthesizing and isolating high-purity N-H ketimines and N-H ketimine hydrochlorides via the dehydration-condensation of ketones with stoichiometric ammonia, generated in situ with inorganic solid acid catalysts. Our methods offer exceptionally broad substrate scope, use non-toxic and reusable catalysts, do not require tedious synthetic steps, are inexpensive, and are suited to large-scale production. Additionally, ketones can be easily converted to N-R ketimines, α-aminonit

SUBMITTER: Shibata S 

PROVIDER: S-EPMC12695866 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature