Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study.

ABSTRACT: To assess the incidence and severity of delirium and subsequent neurological impairment in pediatric intensive care unit (PICU) patients with meningoencephalitis (ME) and sepsis. Prospective study enrolling PICU patients with sepsis or meningoencephalitis (ME) and healthy controls. Daily delirium assessment, repeated electroencephalography, blood sampling at days 1, 3, 5 and lumbar puncture, if clinically indicated, for cerebrospinal fluid (CSF) sampling were performed. Biomarkers of inflammation (CRP, PCT, IL-6), endothelial activation (NT-proCNP), neurodegeneration (NSE, tau), neuroaxonal damage (NfL, NfH, UCHL-1) and glial injury (GFAP, S100B) were measured. Neurological status was assessed using the Functional Status Scale (FSS), the pediatric overall performance category (POPC) and th

SUBMITTER: Klawitter F 

PROVIDER: S-EPMC12695873 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature