RBP2 promotes gastric cancer cell migration by acting as a competitive endogenous RNA to upregulate SOX4 via sponging miR-212-3p.

ABSTRACT: Migration is a critical driver in the initiation and progression of gastric cancer. However, the involvement of RNA-RNA interactions in this process remains poorly understood. Previous work from our group and others has established RBP2 (RB-Binding Protein 2) and SOX4 (SRY-related high-mobility-group box 4) as key regulators of tumor development, influencing processes such as cell proliferation, differentiation, survival, and migration. Here, we demonstrate that RBP2 regulates SOX4 expression at both the mRNA and protein levels via a miRNA- and 3'UTR-dependent mechanism. Integrated bioinformatics and experimental analyses revealed downregulation of miR-212-3p and concomitant overexpression of RBP2 and SOX4 during gastric carcinogenesis. Importantly, miR-212-3p was identified as a shared up

SUBMITTER: Jilan L 

PROVIDER: S-EPMC12695874 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature