Genomic surveillance of HBV and HDV reveals genotype-specific risk of liver disease in central Vietnam.

ABSTRACT: Hepatitis B virus (HBV) genotype distribution, resistance mutations, and hepatitis delta virus (HDV) co-infection play critical roles in disease progression and treatment outcomes yet remain understudied in central Vietnam. This study aimed to understand their characteristics and association with clinical outcomes. Serum from 376 HBV-infected patients in Hue, Vietnam (June 2023-June 2024) was analysed. HBV-DNA and HDV-RNA were extracted and amplified by nested PCR, followed by Sanger sequencing. HBV viral load was quantified using real-time PCR. HBV and HDV genotypes were determined through phylogenetic analysis, and HBV resistance mutation identified using geno2pheno [hbv]. HBV genotype B was predominant (95%), followed by genotypes C (5%) and D (0.3%). Infection with genotype C was signi

SUBMITTER: Cao LC 

PROVIDER: S-EPMC12695881 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature