⁸⁹Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8⁺ immune responses to treatment with radiation and anti-CTLA4.

ABSTRACT: Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study characterized longitudinal CD8⁺ T cell responses in an orthotopic mouse model of breast cancer treated with radiation and anti-CTLA4 by immunohistochemistry and anti-CD8 immunoPET, confirming an early but heterogeneous response induced by combination treatment that is detectable by imaging.

SUBMITTER: Germino EA 

PROVIDER: S-EPMC12695897 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature