Generalized additive mixed models to discern data-driven theoretically informed strategies for public brain, cognitive and mental health.

ABSTRACT: Social isolation is recognized as a public health emergency. However, major guidelines provide vastly different recommendations on how to target it, and no strategy has been substantiated on firm theoretical or empirical grounds, yet. Rose's seminal The Strategy of Preventive Medicine provided a theoretical framework for such arbitrations between approaches. Therein, determining the shape of the relationship between risk factor and outcome is of paramount importance. However, quantitative approaches immediately applying this theory to evidence are still lacking. Thus, in this pre-registered analysis, we pursued a novel approach and employed generalized additive mixed models to model the shape of social isolation's Links to brain, cognitive and mental health outcomes in a well-characterised

SUBMITTER: Lammer L 

PROVIDER: S-EPMC12695978 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature