Plasma P-tau217, GFAP, and NfL as biomarkers for Alzheimer's disease: role in disease stratification, pathological progression, and cognitive decline.

ABSTRACT:

Introduction

Blood-based phosphorylated tau 217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) show promise for Alzheimer's disease (AD), while their links to brain amyloid beta (Aβ)/tau, hippocampal atrophy, and cognitive decline need further investigation.

Methods

A cohort of 1275 participants, representing various cognitive stages, was recruited to examine the links between plasma biomarkers and brain Aβ/tau stages, tau progression, hippocampal atrophy, and cognitive decline.

Results

Plasma p-tau217 effectively distinguished A-T-/A-T+ individuals and A+T+_{Braak III-VI} patients, though it identified early A+T-/A+T+_{Braak I-II} stages only in Aβ+ subjects. Plasma GFAP levels plateau beyond a certain tau thre

SUBMITTER: Pan FF 

PROVIDER: S-EPMC12696028 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature