Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study.

ABSTRACT:

Background

Impaired cerebral glucose metabolism is a hallmark of Alzheimer's disease (AD). Lactate is an alternative brain fuel; however, whole-body lactate metabolism has not been measured in AD.

Methods

The Lactate for Energy and Neurocognition Trial (NCT05207397) was a single-arm trial that enrolled 24 cognitively healthy (CH) older adults and 12 cognitively impaired (CI) participants. Subjects underwent a stable isotope lactate infusion to evaluate lactate metabolism, cognitive testing, and blood biomarker analyses. pTau217, brain-derived tau (BD-tau), pTau181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and brain-derived neurotrophic factor (BDNF) were analyzed by Simoa HD-X (Quanterix).

Results

Lactate metabolic clearance

SUBMITTER: Kemna RE 

PROVIDER: S-EPMC12696042 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature