L-Theanine mitigates skin aging in rats via modulation of the AGEs-RAGE pathway, enhancement of antioxidant defense, and attenuation of inflammation.

ABSTRACT: This study aimed to evaluate the anti-aging effects of L-theanine in a D-galactose-induced aging model in rats and to elucidate its underlying molecular mechanisms. Aging was induced via subcutaneous administration of D-galactose, while L-theanine was delivered orally for eight weeks. Skin aging was induced in rats by daily subcutaneous injection of D-galactose. L-theanine was administered orally for eight weeks. Skin condition was assessed through by macroscopic observation and histological examination. Enzyme-linked immunosorbent assays were conducted to measure oxidative stress parameters, inflammatory cytokines, and AGEs/RAGE expression levels. L-theanine administration significantly improved skin integrity, maintained epidermal thickness and collagen architecture, administration signi

SUBMITTER: Xu D 

PROVIDER: S-EPMC12696091 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature