Free water elimination tractometry reveals local and remote white matter alterations in diffuse gliomas.

ABSTRACT:

Purpose

To apply free water elimination (FWE) tractometry to a real-world clinical imaging dataset to quantify pathology-specific patterns of white matter involvement and peritumoral tissue alterations in diffuse gliomas.

Methods

The University of California San Francisco Preoperative Diffuse Glioma MRI dataset was analyzed using FWE tractometry. Twenty major white matter tracts were reconstructed and each divided into 100 equidistant nodes. Direct tumor involvement was quantified across enhancing tumor, necrotic core, and edema regions. Remote white matter tissue properties were assessed through hemispheric asymmetry analysis of free water-corrected fractional anisotropy (FW-FA), mean diffusivity (FW-MD), and free water fraction (FWF) in non-tumor involved regions at standa

SUBMITTER: Zhou DJ 

PROVIDER: S-EPMC12696142 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature