Evaluation of the safety and efficacy of <i>Sophorae Flavescentis</i> Radix extract in the treatment of inflammatory bowel disease based on zebrafish models.

ABSTRACT:

Background

Sophorae Flavescentis Radix (Kushen) has been employed in Traditional Chinese Medicine (TCM) for over 2,000 years, primarily for its effects in clearing heat and drying dampness, eliminating parasites, and promoting diuresis. Preliminary findings suggest that Kushen extract or its formulations may exhibit potential therapeutic benefits in alleviating inflammatory bowel disease (IBD).

Aims

This study aimed to comprehensively evaluate the safety and efficacy of Kushen extract using a zebrafish model, with a particular focus on intestinal mucosal immunity, and to explore its underlying mechanisms.

Material and methods

The safety and efficacy profile of Kushen extract was comprehensively evaluated in zebrafish model. Network pharmacology combined with tr

SUBMITTER: Chen X 

PROVIDER: S-EPMC12696176 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature