Effects of Cholinesterase Inhibitor Medication on QTc Interval in Memory Clinic Patients.

ABSTRACT:

Background

Cholinesterase inhibitors (ChEIs)-donepezil, rivastigmine, and galantamine-are beneficial in treating Alzheimer disease (AD). However, due to their impact on extra-cerebral acetylcholine signaling, concerns about cardiac adverse effects, including QT interval prolongation, persist. Despite this, evidence-based guidelines for electrocardiogram (ECG) monitoring during ChEI treatment are lacking, and prior studies on ChEIs and corrected QT intervals (QTc) yield inconsistent findings.

Objective

This study aimed to investigate the association between ChEI use and changes in QTc intervals among older adults.

Methods

We collected retrospective data from first-time visitors to the geriatric memory clinic of Turku City Hospital in 2017 and 2019. We included patients

SUBMITTER: Isotalo HK 

PROVIDER: S-EPMC12696191 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature