Evaluation of outcomes associated with antipseudomonal beta-lactams for treatment of methicillin-susceptible <i>Staphylococcus aureus</i> bacteremia: a retrospective cohort analysis.

ABSTRACT:

Background

Treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia with antipseudomonal beta-lactams (APBLs) is a common clinical practice in confirmed or suspected polymicrobial infections. Limited data exist to evaluate the impact of APBL treatment on outcomes in MSSA bacteremia.

Objectives

To determine whether differences in outcomes exist between patients with MSSA bacteremia treated with cefazolin/oxacillin (standard of care; SOC) versus APBLs.

Design

Retrospective cohort study.

Methods

Adult and pediatric patients hospitalized between June 2016 and June 2023 with at least one positive blood culture for MSSA who received at least 14 consecutive days of inpatient therapy with cefazolin, oxacillin, cefepime, piperacillin-tazobacta

SUBMITTER: Fielding M 

PROVIDER: S-EPMC12696287 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature